National Institute on 老化 renews funding for long-running 'living laboratory'

西雅图— The National Institute on 老化 recently awarded the 团体健康-华盛顿大学UW) Adult Changes in Thought (ACT) study a grant of nearly $13 million to continue its work for the next five years through April 2020.

One of the longest-running studies of its kind, the ACT study has been thoroughly tracking what happens with a cohort of randomly selected 团体健康 patients older than 65 as they lead their lives. The study has become a “living laboratory” to understand the aging process—particularly in the brain—and to identify risk factors for conditions including dementia.

这项世界杯下注网站是由Eric B. 拉尔森，医学博士，公共卫生硕士，和 保罗·K. 克莱恩，医学博士，公共卫生硕士, as multi-principal investigators. Dr. Larson is vice president for research at 团体健康, executive director of 团体健康 世界杯下注网站 Institute (GHRI), and a clinical professor of medicine at the UW School of Medicine and of health services at the UW School of Public Health. He began the study as the Alzheimer’s Disease Patient Registry, a registry for Alzheimer’s disease, in 1986. Dr. Crane is a UW School of Medicine professor of medicine and adjunct professor of health services and a GHRI affiliate investigator.

For the next five years, the ACT study will focus on several areas, including these three:

• 多种疾病
  Most older people have several chronic illnesses. How can having various conditions affect brain aging? These conditions include risk factors that can be modified for diseases of the heart and blood vessels.
• 健康老龄化
  Why are some ACT participants who have survived past age 85 still thinking and moving so well? "We've learned about what our research subjects value as they age,” Dr. 拉森说,. “We hope to help them find the best solutions to age well—promoting their independence and providing them with skills to cope with any problems that may happen."
• 大数据
  How can the ACT study continue to be a resource for a variety of collaborators worldwide who are interested in ACT’s rich sources of information from research and clinical visits, 特别是对于 遗传学和脑科学? “Many scientific partners are intrigued by all we have to offer, including detailed information, 精确的诊断, and biostatistical and programming knowhow,” Dr. 克雷恩称.

The participants’ completeness of follow-up is more than 97 percent, thanks to a dedicated group of volunteers and their families. Some have been with the ACT study since 1994, when the cohort formed. “We’re grateful for their efforts and the exquisite information about the history of their lives that contributes to all we’re learning about aging and the brain,” Dr. 拉森说,. “We couldn’t do any of this work without the dedication of our wonderful participants and staff.”

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