美国人使用的处方药比以往任何时候都多. Consequently, they’re coping with more side effects, drug interactions, and costs, 特别是如果他们同时服用多种药物. 凯撒永久华盛顿健康世界杯下注网站所(KPWHRI)的科学家们正站在回答这些问题的前沿. 我们正在世界杯下注网站药物在现实环境中的有益和有害影响, 创新管理和监测药物使用的更好方法.
该世界杯下注网站所为监测药物安全的国家倡议作出贡献,并提供信息,帮助医生和患者权衡各种处方药的风险和益处.
KPWHRI药物使用和患者安全世界杯下注网站的资助者包括 Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the National Institutes of Health, the Patient-Centered Outcomes Research Institute, and other sources. A few projects include:
Marcum ZA, Gold LS, James KT, Meier EN, Turner JA, Kallmes DF, Cherkin DC, Deyo RA, Sherman KJ, Luetmer PH, Avins AL, Griffith B, Friedly JL, Suri P, Heagerty PJ, Jarvik JG. 在腰椎影像学报告中纳入流行病学资料对处方非阿片类药物治疗疼痛的影响. J Gen Intern Med. 2021 Aug;36(8):2237-2243. doi: 10.1007/s11606-021-06627-6. Epub 2021 Feb 8. PubMed
Pocobelli G, Dublin S, Bobb JF, Albertson-Junkans L, Andrade S, Cheetham TC, Salgado G, Griffin MR, Raebel MA, Smith D, Li DK, Pawloski PA, Toh S, Taylor L, Hua W, Horn P, Trinidad JP, Boudreau DM. 2001-2014年期间美国8个健康计划中怀孕期间处方阿片类药物使用的流行率. Pharmacoepidemiol Drug Saf. 2021 Nov;30(11):1541-1550. doi: 10.1002/pds.5312. Epub 2021 Jul 7. PubMed
Penfold RB, Hilt RJ, Schwartz N, Thompson EE, Robb AS, Correll CU, Newton D, Rogalski K, Earls MF, Kowatch RA, Beck A, Yarborough BJ, Crystal S, Kelleher KJ. 建立以症状为中心的模型来指导儿童和青少年抗精神病药物的处方:抗精神病药物更安全和有针对性使用(SUAY)临床试验第一阶段的结果. J Am Acad Child Adolesc Psychiatry. 2022 Jan;61(1):93-102. doi: 10.1016/j.jaac.2021.04.010. Epub 2021 May 4. PubMed
Bender M, Williams M, Cruz MF, Rubinson C. 一项评估临床护士领导护理模式在提高质量和安全结果方面的实施和有效性的世界杯下注网站方案. Nurs Open. 2021 May 3. doi: 10.1002/nop2.910. Online ahead of print. PubMed
Bonomi A, Zeoli AM, Shanahan S, Martin D. 拯救生命:跨机构和个人开展工作,减少最危险人群中的亲密杀人行为. J Fam Violence. 2021 Apr 14;1-4. doi: 10.1007/s10896-021-00266-5. PubMed
Sascha Dublin, MD, PhDSenior Investigator |
Jessica Chubak, PhDSenior Investigator |
Andrea J. Cook, PhDSenior Biostatistics Investigator |
Rita Mangione-Smith, MD, MPHExecutive Director and Senior Investigator, KPWHRI; Vice President for Research and Health Care Innovation, 2022世界杯下注网站 Washington |
Jennifer C. Nelson, PhDDirector, Biostatistics; Senior Investigator |
David E. Arterburn, MD, MPHSenior Investigator |
Susan M. Shortreed, PhDSenior Biostatistics Investigator |
Lisa A. Jackson, MD, MPHSenior Investigator |
Karen Wernli, PhDSenior Investigator |
Onchee Yu, MSPrincipal Collaborative Biostatistician |
Rod L. Walker, MSPrincipal Collaborative Biostatistician |
Robert D. Wellman, MSPrincipal Collaborative Biostatistician |
Gaia Pocobelli, PhDSenior Collaborative Scientist |
Laura Harrington, PhD, MPHAssistant Investigator |
Jennifer F. Bobb, PhDAssociate Biostatistics Investigator |
Weiwei Zhu, MSSenior Collaborative Biostatistician |
Paige D. Wartko, PhD, MPHSenior Collaborative Scientist |
Maricela Cruz, PhDAssistant Biostatistics Investigator |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Noorie Hyun, PhDAssociate Biostatistics Investigator |
Laurel Hansell, MA, MPHCollaborative Scientist |
Jess Mogk, MPHCollaborative Scientist |
Annie Piccorelli, PhDSenior Collaborative Biostatistician |
Susan Heckbert, MD, PhD
University of Washington (UW) Department of Epidemiology; UW Cardiovascular Health Research Unit
David Siscovick, MD, MPH
UW Department of Medicine; UW Department of Epidemiology; UW Cardiovascular Health Research Unit
Leslie Spangler, PhD
Amgen
KPWHRI的Kiel, Matson和Lapham世界杯下注网站了初级保健中妊娠和筛查的使用.
A team led by KPWHRI's Kai Yeung, PharmD, PhD, 回顾了3种治疗方法的成本效益试验结果.
Dr. Sascha Dublin explains why sometimes not 服用药物可能是更安全、更健康的选择.
世界杯下注网站人员需要更大的数据集才能找到有意义的结果. Sascha Dublin and colleagues write in Pediatrics.
New funding will establish an innovation center, 由哈佛朝圣者与KPWHRI和其他机构合作领导.
世界杯下注网站人员发现,处方中枢神经系统活性药物与老年痴呆症患者摔倒风险增加之间存在关系.