Americans are using more prescription drugs than ever. Consequently, they’re coping with more side effects, drug interactions, and costs, especially if they’re using multiple medications. 2022世界杯下注网站 Washington Health Research Institute (KPWHRI) scientists are on the forefront of answering questions about these concerns. We’re studying the beneficial and harmful effects of medications in real-world settings, and innovating better ways to manage and monitor drug use.
The institute contributes to national initiatives to monitor medication safety as well as providing information to help doctors and patients weigh the risks and benefits of various prescription drugs.
Funders of KPWHRI medication use and patient safety research include the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the National Institutes of Health, the Patient-Centered Outcomes Research Institute, and other sources. A few projects include:
Grossman DC, Larson EB, Sox HC. Integrating personalized medicine with population health management: the path forward. JAMA. 2020 Jul 30. doi: 10.1001/jama.2020.1406. [Epub ahead of print]. PubMed
Dublin S, Wartko P, Mangione-Smith R. Studying medication safety in pregnancy: a call for new approaches, resources, and collaborations. Pediatrics. 2020 Jul;146(1):e20201540. doi: 10.1542/peds.2020-1540. Epub 2020 Jun 8. PubMed
Marcum ZA, Hohl SD, Barthold D, Zaslavsky O, Larson EB, Gray SL. Beliefs about benefits and harms of medications and supplements for brain health. Prev Med Rep. 2020 Jan 25;17:101060. doi: 10.1016/j.pmedr.2020.101060. eCollection 2020. PubMed
Shoemaker-Hunt SJ, Evans L, Swan H, Bacon O, Ike B, Baldwin LM, Parchman M. Study protocol for evaluating Six Building Blocks for Opioid Management implementation in primary care practices. Implement Sci Commun. 2020 Feb 26;1:16. doi: 10.1186/s43058-020-00008-6. eCollection 2020. PubMed
Parchman ML, Palazzo L, Austin BT, Blasi P, Henrikson NB, Gundersen G, Ganos E. Taking action to address medical overuse: common challenges and facilitators. Am J Med. 2020 Feb 4. pii: S0002-9343(20)30052-8. doi: 10.1016/j.amjmed.2020.01.001. [Epub ahead of print]. PubMed
Sascha Dublin, MD, PhDSenior Investigator |
Jessica Chubak, PhDSenior Investigator |
Andrea J. Cook, PhDSenior Biostatistics Investigator |
Rita Mangione-Smith, MD, MPHExecutive Director and Senior Investigator, KPWHRI; Vice President for Research and Health Care Innovation, 2022世界杯下注网站 Washington |
Jennifer C. Nelson, PhDDirector, Biostatistics; Senior Investigator |
David E. Arterburn, MD, MPHSenior Investigator |
Susan M. Shortreed, PhDSenior Biostatistics Investigator |
Lisa A. Jackson, MD, MPHSenior Investigator |
Karen Wernli, PhDSenior Investigator |
Onchee Yu, MSPrincipal Collaborative Biostatistician |
Rod L. Walker, MSPrincipal Collaborative Biostatistician |
Robert D. Wellman, MSPrincipal Collaborative Biostatistician |
Gaia Pocobelli, PhDSenior Collaborative Scientist |
Laura Harrington, PhD, MPHAssistant Investigator |
Jennifer F. Bobb, PhDAssociate Biostatistics Investigator |
Weiwei Zhu, MSSenior Collaborative Biostatistician |
Paige D. Wartko, PhD, MPHSenior Collaborative Scientist |
Maricela Cruz, PhDAssistant Biostatistics Investigator |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Noorie Hyun, PhDAssociate Biostatistics Investigator |
Laurel Hansell, MA, MPHCollaborative Scientist |
Jess Mogk, MPHCollaborative Scientist |
Annie Piccorelli, PhDSenior Collaborative Biostatistician |
Susan Heckbert, MD, PhD
University of Washington (UW) Department of Epidemiology; UW Cardiovascular Health Research Unit
David Siscovick, MD, MPH
UW Department of Medicine; UW Department of Epidemiology; UW Cardiovascular Health Research Unit
Leslie Spangler, PhD
Amgen
Use in pregnancy and screening in primary care studied by KPWHRI’s Kiel, Matson, and Lapham.
New study results in more precise language in the federally mandated warning about this possibility.
A study led by Dr. Sascha Dublin finds similar outcomes for 3 hypertension medications, filling an evidence gap.
A team led by KPWHRI's Kai Yeung, PharmD, PhD, reviewed trial results for cost-effectiveness of 3 treatments.
Dr. Sascha Dublin explains why sometimes not taking medications may be a safer and healthier choice.
New research examines providers’ notes to understand patients’ cannabis use and health conditions.
Health care is increasingly online—KPWHRI is studying telehealth options for opioid use disorder and chronic pain.
Researchers need much bigger data sets to find outcomes that matter, Dr. Sascha Dublin and colleagues write in Pediatrics.
Evidence from Dr. Dublin’s work helps patients and doctors make the best care choices in pregnancy.
New funding will establish an innovation center, to be led by Harvard Pilgrim in partnership with KPWHRI and others.
Dr. David Arterburn discusses reassuring news from his PCORnet study of the most widely used anti-obesity drug in the United States.
Researchers find a relationship between prescribed central nervous system-active medications and increased risk of falling among older people with dementia.